Genus Ziziphus: A comprehensive review on ethnopharmacological, phytochemical and pharmacological properties.
Identifieur interne : 000674 ( Main/Exploration ); précédent : 000673; suivant : 000675Genus Ziziphus: A comprehensive review on ethnopharmacological, phytochemical and pharmacological properties.
Auteurs : Ezzouhra El Maaiden [Maroc] ; Youssef El Kharrassi [Maroc] ; Nagib A S. Qarah [Yémen] ; Abdel Khalid Essamadi [Maroc] ; Khadija Moustaid [Maroc] ; Boubker Nasser [Maroc]Source :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Composés phytochimiques (isolement et purification), Composés phytochimiques (pharmacologie), Composés phytochimiques (toxicité), Ethnobotanique (MeSH), Ethnopharmacologie (MeSH), Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Extraits de plantes (toxicité), Humains (MeSH), Médecine traditionnelle (MeSH), Phytothérapie (MeSH), Ziziphus (composition chimique).
- MESH :
- composition chimique : Ziziphus.
- isolement et purification : Composés phytochimiques, Extraits de plantes.
- pharmacologie : Composés phytochimiques, Extraits de plantes.
- toxicité : Composés phytochimiques, Extraits de plantes.
- Animaux, Ethnobotanique, Ethnopharmacologie, Humains, Médecine traditionnelle, Phytothérapie.
English descriptors
- KwdEn :
- Animals (MeSH), Ethnobotany (MeSH), Ethnopharmacology (MeSH), Humans (MeSH), Medicine, Traditional (MeSH), Phytochemicals (isolation & purification), Phytochemicals (pharmacology), Phytochemicals (toxicity), Phytotherapy (MeSH), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Plant Extracts (toxicity), Ziziphus (chemistry).
- MESH :
- chemical , isolation & purification : Phytochemicals, Plant Extracts.
- chemical , pharmacology : Phytochemicals, Plant Extracts.
- chemical , toxicity : Phytochemicals, Plant Extracts.
- chemistry : Ziziphus.
- Animals, Ethnobotany, Ethnopharmacology, Humans, Medicine, Traditional, Phytotherapy.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE
The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this review: This review article documents and critically assesses, for the first time; up to date categorized information about botanical traits, distribution, traditional uses, phytochemistry, pharmacological and toxicological effects of Ziziphus species.
METHODS
Information was collected systematically from electronic scientific databases including Google Scholar, Science Direct, PubMed, Web of Science, ACS Publications, Elsevier, SciFinder, Wiley Online Library and CNKI, as well as other literature sources (e.g., books).
KEY FINDINGS
The phytochemical investigations of plants of this genus have led to the identification of about 431 chemical constituents. Cyclopeptide alkaloids and flavonoids are the predominant groups. The crude extracts and isolated compounds exhibit a wide range of in vitro and in vivo pharmacologic effects, including antimicrobial, antitumour, antidiabetic, antidiarrhoeal, anti-inflammatory, antipyretic, antioxidant and hepatoprotective activities. Toxicity studies indicate that Ziziphus species seems to be non-toxic at typical therapeutic doses.
CONCLUSION
Phytochemical and pharmacological studies have demonstrated that Ziziphus species are important medicinal herbs with prominent bioactivities. The focus so far has only been on ten species; however, plants of this genus can potentially yield a wide range of other products with different properties. Meticulous studies on pharmaceutical standardisation, mode of action of the active constituents and toxicity of Ziziphus species are needed to meet the growing demands of the pharmaceutical industry and to exploit their preventive and therapeutic potential fully.
DOI: 10.1016/j.jep.2020.112950
PubMed: 32450235
Affiliations:
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Le document en format XML
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<term>Humans (MeSH)</term>
<term>Medicine, Traditional (MeSH)</term>
<term>Phytochemicals (isolation & purification)</term>
<term>Phytochemicals (pharmacology)</term>
<term>Phytochemicals (toxicity)</term>
<term>Phytotherapy (MeSH)</term>
<term>Plant Extracts (isolation & purification)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant Extracts (toxicity)</term>
<term>Ziziphus (chemistry)</term>
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<term>Composés phytochimiques (isolement et purification)</term>
<term>Composés phytochimiques (pharmacologie)</term>
<term>Composés phytochimiques (toxicité)</term>
<term>Ethnobotanique (MeSH)</term>
<term>Ethnopharmacologie (MeSH)</term>
<term>Extraits de plantes (isolement et purification)</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Extraits de plantes (toxicité)</term>
<term>Humains (MeSH)</term>
<term>Médecine traditionnelle (MeSH)</term>
<term>Phytothérapie (MeSH)</term>
<term>Ziziphus (composition chimique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Phytochemicals</term>
<term>Plant Extracts</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phytochemicals</term>
<term>Plant Extracts</term>
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<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Phytochemicals</term>
<term>Plant Extracts</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ziziphus</term>
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<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Ziziphus</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Composés phytochimiques</term>
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<term>Ethnobotany</term>
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<term>Medicine, Traditional</term>
<term>Phytotherapy</term>
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<term>Ethnopharmacologie</term>
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<front><div type="abstract" xml:lang="en"><p><b>ETHNOPHARMACOLOGICAL RELEVANCE</b>
</p>
<p>The genus Ziziphus (Rhamnaceae) contains 58 accepted species that are extensively used by local people and medicinal practitioners in arid and semi-arid regions for the treatment of diarrhoea, dysentery, cholera, diabetic, hypertension, inflammation, intestinal spasm, liver, malaria and other diseases. Aims of this review: This review article documents and critically assesses, for the first time; up to date categorized information about botanical traits, distribution, traditional uses, phytochemistry, pharmacological and toxicological effects of Ziziphus species.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Information was collected systematically from electronic scientific databases including Google Scholar, Science Direct, PubMed, Web of Science, ACS Publications, Elsevier, SciFinder, Wiley Online Library and CNKI, as well as other literature sources (e.g., books).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>KEY FINDINGS</b>
</p>
<p>The phytochemical investigations of plants of this genus have led to the identification of about 431 chemical constituents. Cyclopeptide alkaloids and flavonoids are the predominant groups. The crude extracts and isolated compounds exhibit a wide range of in vitro and in vivo pharmacologic effects, including antimicrobial, antitumour, antidiabetic, antidiarrhoeal, anti-inflammatory, antipyretic, antioxidant and hepatoprotective activities. Toxicity studies indicate that Ziziphus species seems to be non-toxic at typical therapeutic doses.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Phytochemical and pharmacological studies have demonstrated that Ziziphus species are important medicinal herbs with prominent bioactivities. The focus so far has only been on ten species; however, plants of this genus can potentially yield a wide range of other products with different properties. Meticulous studies on pharmaceutical standardisation, mode of action of the active constituents and toxicity of Ziziphus species are needed to meet the growing demands of the pharmaceutical industry and to exploit their preventive and therapeutic potential fully.</p>
</div>
</front>
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<name sortKey="El Kharrassi, Youssef" sort="El Kharrassi, Youssef" uniqKey="El Kharrassi Y" first="Youssef" last="El Kharrassi">Youssef El Kharrassi</name>
<name sortKey="Essamadi, Abdel Khalid" sort="Essamadi, Abdel Khalid" uniqKey="Essamadi A" first="Abdel Khalid" last="Essamadi">Abdel Khalid Essamadi</name>
<name sortKey="Moustaid, Khadija" sort="Moustaid, Khadija" uniqKey="Moustaid K" first="Khadija" last="Moustaid">Khadija Moustaid</name>
<name sortKey="Nasser, Boubker" sort="Nasser, Boubker" uniqKey="Nasser B" first="Boubker" last="Nasser">Boubker Nasser</name>
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<country name="Yémen"><noRegion><name sortKey="Qarah, Nagib A S" sort="Qarah, Nagib A S" uniqKey="Qarah N" first="Nagib A S" last="Qarah">Nagib A S. Qarah</name>
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